Khapre® DS: Digestive Stress Formula

Khapre® DS: Digestive Stress Formula

Khapre® – DS

Practitioners: please page down to view scientific comparison studies and page source references

Digestive stress problems are a major health issue. The number of recorded visits to doctors in the US with diseases of the digestive system in 2009-2010 was 51.0 million(1). Simple discomfort during the day & especially after meals is far more common and often leads to Irritable Bowel Disorders (IBD).

Khapre® – DS  is a digestive stress formula(1a).

Traditionally safe-to-use(6), scientific studies show that it’s prime ingredient possesses significant anti-inflammatory & pain relieving activity on acute and chronic inflammation via oral application(5)(7).

Khapre® – DS  is designed as an ingredient in preventative health products such as multi-vitamins, weight-loss, de-tox, and health foods.

Health foods that target allergy sufferers such as gluten and dairy intolerance and those that choose a high anti-oxidant intake are the typical beneficiaries of the Khapre® – DS  formula.

Other unique and significant properties of the Khapre® – DS  formula is that it’s prime ingredient has been shown to inhibit liver toxicity(2a) and inhibit the growth of colon cancer cells(2b) in laboratory tests.

It may also assist to:

  • Soothe gastro-intestinal inflammation(3) that results from Irritable Bowel Disorders (IBD) or simple food related allergies such as gluten or dairy intolerance; and
  • Provide high anti-oxidant protection(4) of the gut lining. Healthier gut cells promote better absorption of nutrients.

R&D:  Bioactive is continuing scientific research in this area focused towards developing more targeted anti-inflammatory pharmaceutical prescription drugs and OTC (over the counter) products.

Growth Markets:  Digestive health is a massive global market that encompasses treatment and prevention, but influences major Complementary Health market segments such as:

  • Weight-loss: The global weight-loss market is predicted to reach $672 Billion by 2015(8a). The US weight-loss market in 2010, in one of the most challenging economic times was worth $60.9 Billion(8b).
  • Vitamins & Supplements: The global vitamin and supplement market is worth $68 billion(8c).

Disclaimer: Please note that any statements aligned to product descriptions on this website and the products themselves are in varying stages of evaluation by the Therapeutic Goods Administration in Australia (TGA) & the Food and Drug Administration in the United States of America (FDA). These products are not intended to diagnose, treat, cure or prevent any disease. 

Bioactive recommend the three pillars of health, a balanced diet with plenty of fresh filtered water, regular daily exercise and a good night’s sleep.

(1a) – Contact Us to find out more



Scientific studies: To see an overview of the R&D program and scientific studies comparing Bioactive extracts to other pharmaceutical substances click on Bioactive Research

Page references:

(1) “These Doctors appointments revealed digestive problems ‘as the primary diagnosis’; ‘Doctors’ refers to physician offices, hospital outpatient and emergency departments”; Source:

(2a) Source:

  •  Ojo OO, Nadro MS, Tella IO, 2006. Protection of rats by extracts of some common Nigerian trees against acetaminophen-induced hepatotoxicity. African Journal of Biotechnology Vol 5 (9), pp 755-760, 2 May 2006

(2b) Source:

  • Androulakis, X.M., Muga, S.J., Chen, F., Koita, Y., Toure, B. & Wargovich, M.J., 2006. Chemopreventive effects of Khaya senegalensis bark extract on human colorectal cancer. Anticancer Research 26(3B): 2397–2405
  • Bioactive blind studies conducted in an independent laboratory concluded an anti-cancer marker profile of key oncology targets AKT1 and EGF Receptor averaging greater than 98% effective.

(3) Source: Bioactive blind studies conducted in an independent laboratory concluded an anti-inflammatory COX2 & Caspase 3 marker profile averaging greater than 95% effective.

(4) Source:

  • Bioactive blind studies conducted in an independent laboratory concluded an anti-oxidant free radical scavenger ABTS profile averaging greater than 95% effective.
  • “This strong antioxidant activity is comparable to that of BHT: antioxidant food additive E321, regarding the DPPH free scavenging activity”, (E321 is approved by the European Union and the FDA) Quote from paper: Zhang H. December 2008; CHARACTERIZATION OF BIOACTIVE PHYTOCHEMICALS FROM THE STEM BARK OF AFRICAN MAHOGANY Khaya senegalensis (MELIACEAE); A PhD Food Technology Dissertation Presented to the Graduate School of Clemson University, Clemson, South Carolina USA.

(5) Source: “Conclusion: In all experimental models used in this study, AKS – Aqueous stem bark extract of Khaya Senegalensis exhibited significant anti-inflammatory and antinociceptive (pain relief) properties which compare favourably well with the effects produced by the standard drugs used. These findings provide scientific basis to justify the traditional use of the plant in inflammatory diseases. The study showed that Khaya senegalensis is a medicinal plant with good potential for the development of new anti-inflammatory drugs. “; Kolawole OT, Akiibinu MO, Ayankunle AA and Awe EO., 2013. Evaluation of Anti-inflammatory and Antinociceptive Potentials of Khaya senegalensis A. Juss (Meliaceae) Stem Bark Aqueous Extract. British Journal of Medicine & Medical Research, 3(2): 216-229, 2013

(6) Safe to use: Being the basis for the TGA approval as a new permissible ingredient for use in Listed Medicines, Traditional medicine applications over centuries classify the Khapre®  ingredients as GRAS (Generally Regarded As Safe). In addition, Bioactive has undertaken stringent safety profiling on their own supply of plant material to confirm the traditional safety claims. Reference source:

  • The Bioactive Group conducted Cytotoxicity, Mediator release, TNFalpha induced PGE2 expression Assays on their own organic supply of plant material which registered negative for cell death (cytotoxicity).
  • Reference is also sited to the following papers:
    • R. G. Ayo, O. T. Audu and J. O. Amupitan, 2007; Physico-chemical characterization and cytotoxicity studies of seed extracts of Khaya senegalensis (Desr.) A. Juss. African Journal of Biotechnology Vol. 6 (7), pp. 894-896, 2 April 2007;
    • OJO, O. O.1, NADRO, M. S.2 and TELLA, I. O., 2006; Protection of rats by extracts of some common Nigerian trees against acetaminophen-induced Hepatotoxicity; African Journal of Biotechnology Vol. 5 (9), pp. 755-760, 2 May 2006
    • J D Audu-Peter, P O Olorunfemi, N Njoku; 2006; Antimicrobial and pharmaceutical properties of Khaya senegalensis seed oil; Journal of Pharmacy and Bioresources Vol. 3 (1) 2006: pp. 19-24

(7) Possible side effects: Taken as an oral formulation, known side effects may include diarrhoea, polyuria, and general weakness.  These side effects are rare and thought to be indicative of the de-tox properties of the Khapre®  ingredients. As in any de-tox or weight-loss preparation, additional fresh water should always be consumed. If they persist see your doctor. Reference source: Side effects from traditional medicine: Tchacondo T. Et al, pub 2010. Herbal Remedies and Their Adverse Effects in Tem Tribe Traditional Medicine in Togo. African Journal of Traditional, Complementary and Alternative Medicines, 2011;8(1):45-60.

(8) Source: