Khapre® J Osteo: Joint Formula Range

Khapre® J Osteo: Joint Formula Range

Khapre® – J Osteo

Practitioners: please page down to view scientific comparison studies and page source references

Rheumatic inflammation, such as arthritis, and associated joint pain is being experienced by more people and at an ever younger age. One in five (22%) adults in the United States report having doctor diagnosed arthritis and one in 250 children are sufferers, costing 128 billion dollars annually(1).

Khapre® – J Osteo  is a pain relieving anti-inflammatory joint formula designed as an ingredient in natural anti-inflammatory and multi-vitamin products(1a).

Scientific studies show that it’s prime ingredient possesses significant anti-inflammatory & pain relieving activity on acute and chronic inflammation via oral & topical application(2).

Traditionally safe-to-use(6), the high potency characteristics of these natural plant derived anti-inflammatory ingredients has been laboratory tested by Bioactive to be extremely effective(3). The active ingredients are used to treat associated inflammatory pain in traditional medicine “as anodyne in cases of rheumatism”(4).

Independent studies have shown that a total extract of the Khapre® – J OsteoJel  ingredients exerted as strong or even stronger anti-inflammatory effects than each of its fractions when applied as an anti-inflammatory ointment(5).

The oral formulation(7) is Khapre® – J Osteo

The topical formulation is Khapre® – J OsteoJel

Bioactive is continuing scientific research in this area focused towards developing more targeted anti-inflammatory pharmaceutical products.


Disclaimer: Please note that any statements aligned to product descriptions on this website and the products themselves are in varying stages of evaluation by the Therapeutic Goods Administration in Australia (TGA) & the Food and Drug Administration in the United States of America (FDA). These products are not intended to diagnose, treat, cure or prevent any disease. 

Bioactive recommend the three pillars of health, a balanced diet with plenty of fresh filtered water, regular daily exercise and a good night’s sleep.


(1a) Contact Us to find out more


Scientific studies: To view scientific studies comparing Bioactive extracts to other pharmaceutical substances click on Bioactive Research

Page references:

(1) Source: http://www.cdc.gov/arthritis/data_statistics/arthritis_related_stats.htm

  • One in five (22%) adults in the United States report having doctor diagnosed arthritis. MMWR 2010;59(39);1261-1265. [Data Source: 2007–2009 NHIS]
  • An estimated 294,000 children under age 18 have some form of arthritis or rheumatic condition; this represents approximately 1 in every 250 children in the U.S. Arthritis Care Res 2007;57:1439-1445 [Data Source: 2001–2004 National Ambulatory Medical Care Survey and 2001–2004 National Hospital Ambulatory Medical Care Survey]
  • In 2003, the total cost attributed to arthritis and other rheumatic conditions in the United States was 128 billion dollars, up from 86.2 billion dollars in 1997. MMWR 2007;56(01):4-7. [Data Source: 2003 Medical Expenditure Panel Survey]

(2) Source: “Conclusion: In all experimental models used in this study, AKS – Aqueous stem bark extract of Khaya Senegalensis exhibited significant anti-inflammatory and antinociceptive (pain relief) properties which compare favourably well with the effects produced by the standard drugs used. These findings provide scientific basis to justify the traditional use of the plant in inflammatory diseases. The study showed that Khaya senegalensis is a medicinal plant with good potential for the development of new anti-inflammatory drugs. “; Kolawole OT, Akiibinu MO, Ayankunle AA and Awe EO., 2013. Evaluation of Anti-inflammatory and Antinociceptive Potentials of Khaya senegalensis A. Juss (Meliaceae) Stem Bark Aqueous Extract. British Journal of Medicine & Medical Research, 3(2): 216-229, 2013

(3) Source: Bioactive blind studies conducted in an independent laboratory concluded an anti-inflammatory COX2 & Caspase 3 marker profile averaging in excess of 95% effective; (Bioactive Solutions Pty Ltd Australian Innovation Patent Application No. 2013100366).

(4) Source: Traditional medicine reference 2013: Nikiema, A. & Pasternak, D., 2008. Khaya senegalensis (Desr.) A.Juss. [Internet] Record from PROTA4U. Louppe, D., Oteng-Amoako, A.A. & Brink, M. (Editors). PROTA (Plant Resources of Tropical Africa), Wageningen, Netherlands.

(5) Thioune O, Diallo AK, Diop AB, Ngom S and Lo I: Fractionation of the total extract of Khaya senegalensis barks. Interest in the formulation of an anti-inflammatory ointment Dakar Med 48: 68-71, 2003.

 (6) Safe to use: Traditional medicine applications over centuries classify the Khapre®  ingredients as GRAS (Generally Regarded As Safe). In addition, Bioactive has undertaken stringent safety profiling on their own organic & 3rd party supply of plant material to confirm the traditional safety claims. Reference source:

  • Bioactive Solutions conducted Cytotoxicity, Mediator release, TNFalpha induced PGE2 expression Assays on their own organic supply of plant material which registered negative for cell death (cytotoxicity).
  • Reference is also sited to the following papers:
    • R. G. Ayo, O. T. Audu and J. O. Amupitan, 2007; Physico-chemical characterization and cytotoxicity studies of seed extracts of Khaya senegalensis (Desr.) A. Juss. African Journal of Biotechnology Vol. 6 (7), pp. 894-896, 2 April 2007;
    • OJO, O. O.1, NADRO, M. S.2 and TELLA, I. O., 2006; Protection of rats by extracts of some common Nigerian trees against acetaminophen-induced Hepatotoxicity; African Journal of Biotechnology Vol. 5 (9), pp. 755-760, 2 May 2006
    • J D Audu-Peter, P O Olorunfemi, N Njoku; 2006; Antimicrobial and pharmaceutical properties of Khaya senegalensis seed oil; Journal of Pharmacy and Bioresources Vol. 3 (1) 2006: pp. 19-24

(7) Possible side effects: Taken as an oral formulation, known side effects may include diarrhoea, polyuria, and general weakness .  These side effects are rare and thought to be indicative of the general de-tox properties of the Khapre®  ingredients. If these side effects were to arise, additional fresh water should always be consumed. If they persist see your doctor. Reference source: Side effects from traditional medicine: Tchacondo T. Et al, pub 2010. Herbal Remedies and Their Adverse Effects in Tem Tribe Traditional Medicine in Togo. African Journal of Traditional, Complementary and Alternative Medicines, 2011;8(1):45-60.